Detalhe da pesquisa
1.
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
Nature
; 538(7625): 344-349, 2016 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27602946
2.
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.
Proc Natl Acad Sci U S A
; 116(4): 1414-1419, 2019 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30617067
3.
TLR4 agonist protects against Trypanosoma cruzi acute lethal infection by decreasing cardiac parasite burdens.
Parasite Immunol
; 42(10): e12769, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32592180
4.
The TLR4 antagonist Eritoran protects mice from lethal influenza infection.
Nature
; 497(7450): 498-502, 2013 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23636320
5.
Vaccine-Linked Chemotherapy Improves Benznidazole Efficacy for Acute Chagas Disease.
Infect Immun
; 86(4)2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29311242
6.
Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo.
Mol Pharmacol
; 85(3): 429-40, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24342772
7.
Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria.
Proc Natl Acad Sci U S A
; 108(9): 3689-94, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21303985
8.
Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis.
Front Microbiol
; 15: 1346068, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38362501
9.
The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection.
bioRxiv
; 2023 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37503013
10.
The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection.
PLoS Negl Trop Dis
; 17(11): e0011519, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37988389
11.
Vaccine-linked chemotherapy improves cardiac structure and function in a mouse model of chronic Chagas disease.
Front Cell Infect Microbiol
; 13: 1106315, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36844399
12.
Localized cardiac metabolic trajectories and post-infectious metabolic sequelae in experimental Chagas disease.
Res Sq
; 2023 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36711878
13.
Vaccine-linked chemotherapy with a low dose of benznidazole plus a bivalent recombinant protein vaccine prevents the development of cardiac fibrosis caused by Trypanosoma cruzi in chronically-infected BALB/c mice.
PLoS Negl Trop Dis
; 16(9): e0010258, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36095001
14.
Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development.
EBioMedicine
; 80: 104065, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35598441
15.
Vaccine-linked chemotherapy induces IL-17 production and reduces cardiac pathology during acute Trypanosoma cruzi infection.
Sci Rep
; 11(1): 3222, 2021 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33547365
16.
E6201, a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-1 and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase-1: in vivo effects on cutaneous inflammatory responses by topical administration.
J Pharmacol Exp Ther
; 335(1): 23-31, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20627998
17.
Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III.
Bioorg Med Chem Lett
; 20(10): 3155-7, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20399648
18.
Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead, II.
Bioorg Med Chem Lett
; 20(10): 3047-9, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20427182
19.
The role of medicine donations in the global programme for the elimination of lymphatic filariasis.
Int Health
; 13(Suppl 1): S39-S43, 2020 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33349878
20.
Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase.
Protein Sci
; 29(3): 779-788, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31930594